Homocysteine accelerates hepatocyte autophagy by upregulating TFEB via DNMT3b-mediated DNA hypomethylation
Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes.High level of homocysteine (Hcy) promotes autophagy in hepatocytes, but the underlying mechanism is still unknown.Here, we investigate the relationship between Hcy-induced autophagy level and the expression of nuclear transcription factor EB (TFEB).The results show